January 17, 2017

Harvard Curriculum Vitae

Judul: Harvard Curriculum Vitae
Penulis: J. Harthorne

Date Prepared: October 18th, 2010
Name: John Warren Harthorne
Office Address: Yawkey 5B, Massachusetts General Hospital; 55 Parkman, Boston, Mass. 02114
Home Address: 33 Highland Circle, Wayland, Massachusetts 01778
Work Phone: (617) 726-2876; (617) 726-2877)
Work Email: HYPERLINK "mailto:jharthorne@partners.org" jharthorne@partners.org
harthorne.john@mgh.harvard.eduWork FAX: (617) 726-5988
Place of Birth: Westbrook, Maine
HYPERLINK "http://cv.hms.harvard.edu/index.php?page=education" \o "click for detailed instructions"Education
Year Degree
(Honors) Fields of Study (Thesis advisor for doctoral research degrees) Institution
2003 BA (Cum Laude)
Masters degree(honorary) Chemistry Major
MD degree
Medicine Bowdoin College
Brunswick, Maine 04011
McGill University School
Of Medicine
Montreal, Quebec, Canada
Harvard Medical School
Postdoctoral TrainingYear(s) Title Specialty/Discipline
(Lab PI for postdoctoral research) Institution
1962-65 Internship
Jr. Resident
Captain, U.S. Army
Captain, U.S. Army
Ass.t Resident
Clinical and Research Fellow
Teaching Fellow Rotating General
Medical Officer
Medical Officer
Maine Medical Center
Portland, Maine 04101
Montreal General Hospital
Montreal, Quebec, Canada
43 Mobile Army Surgical Hospital; Uijongbu, Korea
Valley Forge General Hospital; Phoenixville, Pa.
Montreal General Hospital
Montreal Quebec, Canada
Massachusetts General Hospital Boston, Mass. 02114
Harvard Medical School
Boston, Mass
Faculty Academic AppointmentsYear(s) Academic Title Department Academic Institution
2003 Research Associate in Medicine
Instructor in Medicine
Assistant Professor of Medicine
Lecturer in Medicine
Associate Professor of Medicine
Professor of Medicine
Harvard Medical School
Harvard Medical School
Harvard Medical School
Tufts Medical School
Harvard Medical School
Harvard Medical School
Appointments at Hospitals/Affiliated InstitutionsYear(s) Position Title Department (Division, if applicable) Institution
1986- Clinical Assistant in Medicine
Assistant in Medicine
Director Cardiac Catheter Lab MGH
Director Pacemaker Services
Associate Physician
Massachusetts General Hospital
Massachusetts General Hospital
Massachusetts General Hospital
Massachusetts General Hospital
Massachusetts General Hospital
Massachusetts General Hospital
Other Professional PositionsYear(s) Position Title Institution
1969- 72
1979 – 81
1990 -
1990 -
1990 -
2000 -
2005 - Chief, Medical Service
Medical Officer
Cardiology Consultant
Visiting Cardiologist
Lecturer in Medicine
Visiting Cardiologist
Consulting Staff
Founder and first President
Board Member
Class Agent and Annual Fund Raiser
Chairman, Committee on Deferred Giving
Consultant, Board Member, and fund raiser 43rd Mobile Army Surgical Hospital, Korea
Valley Forge General Hospital, Phoenixville, Pa.
Bunker Hill Health Center, Charlestown, Mass.
Worcester Memorial Hospital, Worcester, Mass.
Tufts University School of Medicine, Boston, Mass.
St. Elizabeths Hospital, Brighton, Mass.
Boston Pacemaker Club (501 C3)
Mount Auburn Hospital, Cambridge, Mass.
North American Society of Pacing and Electrophysiology (NASPE) (501 C3)
North American Society of Pacing and Electrophysiology (NASPE)
Pacemaker Committee, American College of Cardiology
International Cardiac Pacing and Electrophysiology Society (ICPES)
Bowdoin College, Brunswick, Maine
Bowdoin College, Brunswick, Maine
American Medical Legal Foundation; Philadelphia, Pa.
TeamHeart; a Medical and Surgical mission to Rwanda (501C-3)
Major Administrative Leadership Positions
Year(s) Position Title Institution (note if specific department)
1975 - 80
1974 - 2008
1974 -
1979 - Director, Cardiac Catheterization Laboratory
Principal Investigator
Director, Pacemaker Services
Founder, first President, Treasurer and member of multiple boards Massachusetts General Hospital
Coronary Artery Surgical Study (CASS) NHLBI Contract: NO1-HV-32985 MGH
Massachusetts General Hospital, Boston, Mass.
Boston Pacemaker Club (501C3)
North American Society of Pacing and Electrophysiology (NASPE – now Heart Rhythm Society (HRS)
[ a global, professional society of 5000+ cardiologists, surgeons, engineers, nurses, and technicians directed toward the technology, indications and training of staff involved in pacemaker and defibrillator therapy.]
National and International
Year(s) Position Title Institution (note if specific department)
1984 –
1979 - present Chairman, Pacemaker Committee
NASPE / HRS Committees
Budget and Finance
Fund Raising
Government Relations
Board of Trustees
Executive Committee
Long Range Planning
Oral History
Regional councilors
Advisory Council
American College of Cardiology
North American Society of Pacing and Electrophysiology - now Heart Rhythm Society; Washington, D.C.
Committee Service
Year(s) of
Membership Name of Committee Institution/Organization
Dates of Role(s) Title of Role(s)
1975 – 80
1980 – 86
1990 - Trustees Volunteer Advisory Committee
Utilisation Review Committee
Partners Purchasing Department: Annual budget Committee for cardiac Arrhythmia Devices Massachusetts General Hospital
Massachusetts General Hospital
Massachusetts General Hospital
International Committee Assignments:
1990 – presentInternational Committee on PacingOrganizes quadrennial World
and Electrophysiology (ICPES)Congresses
Professional SocietiesYear(s) of
Membership Society Name Dates of Role(s) Title of Role(s)
1959 -
1965 -
1965 -
1966 -
1968 -
1975 -
1979 -
1980 -
2008 - 38th Parallel Medical Society
Aesculapian Society
American College of Physicians
Massachusetts Medical Society
Suffolk Medical Society
American College of Cardiology
North American Society of Pacing and Electrophysiology
Paul Dudley White Society
TeamHeart Medical Mission to Rwanda Founder and Member; Seoul, Korea
Harvard Medical School
Member and Fellow
Member and Fellow
Founder, President and current member
Founder and consulting cardiologist: A 501 C3 mission directed toward cardiac diagnosis and surgical treatment of patients with heart disease.
Editorial ActivitiesJournals for which you serve as a reviewer
PACE: The Journal of Pacing and Clinical Electrophysiology
Heart Beat International
European Journal of Cardiology
Other Editorial Roles
Year(s) Role Journal Name
Consultant American Medical Legal Foundation Analysis and review of quality of care provided by physicians and hospitals
Honors and PrizesYear Name of Honor/Prize Awarding Organization Achievement for which awarded
(if unclear from award title)
1984 -
1992 -
1992 -
1993 -
1994 -
2000 -
2000 –
2001 - Bowdoin College
North American Society of Pacing and Electrophysiology (NASPE)
Founders Award
Distinguished Service Award
Citation: Best Doctors in America
Citation: Best Doctors in Boston
Citation: Outstanding Scientists of the 20th Century
Who's who in America
Founders Award B.A. (Chemistry)
Washington, D.C.
Designé Cum Laude
Founder and First President
Woodward / White Publishers
Competency Exam in Pacing and Electrophysiology hosted by NASPE
Boston Magazine
International Biographical Center, Cambridge, England Melrose Press Ltd.
55th Edition 2001 Marquis: Who's Who
North American Society of Pacing and Electrophysiology
Report of Funded and Unfunded Projects
Funding InformationPast
Grant title Grant title
Grant type and number
Role on Project (if PI or site PI, total indirect costs)
Description of the major goals
1975 – 80 National Institutes of Health LBI NO1-HV-32985 Coronary Artery Surgical Study (CASS)
Report of Local Teaching and Training
Formal Teaching of Residents, Clinical Fellows and Research Fellows (post-docs)
1.) John McDermott (1974)Surgeon, Texas Heart
Redmond, Washington
2.) Hilbert J. Thalen (1976)Prof. of Medicine Univ.Groningen, HollandGroningen (Deceased)
3.) Fred Poulin (1978-1981)Chief of Cardiology, Mercy Portland, Maine Hospital; Ass't Prof,Univ.
Vermont Med School
4.) David Steinhaus(1982-1983)Prof.Med Univ.Missouri Med School Kansas City, Mo Director EP & Pacing & Exec.Med.Dir'r
Mid America Heart Institute. Currently vice President of Medtronic

5.) Vincent DiCola(1981-1983)Ass't Prof. Med. Yale and U.Conn
New Haven, Ct.

6.) Andrew Eisenhauer (?1983)Director, interventional Cath
Boston, Mass.Brigham & Womens
7.) Stanley Schneller (1984-1985)Assoc.Prof.Med. Columbia Univ.
New York City
8.) Gerald Zisfein (?1985-1986)Ass't Prof Med. SUNY &
Long Island, N.Y. Director, Cath Lab So.Nassau Hospital

9.) William Stewart(1984)Cleveland Clinic Echo Dept.
Cleveland, Ohio
10.).Marc Schoenfeld (1985-1986)Assoc.Prof.Med Yale
New Haven, Ct. Director EP & Pacing St.Barnabas
11.) Ellen Jansyn (1987)Cardiologist Hoffman Estates Hosp.Chicago, Illinois

12.) Donald Rediker (1988) Interventional Cardiologist
San Diego, Calif. Mission Viejo Hosp.
13.) Jeff Rottman (1987-1988)Assoc.Prof.Med.Cardiol.&Pharm.
Memphis, Tenn.Vanderbilt Univ.;Assoc.Dir.Cardiology14.) Lawrence Gering (1988-1989)Interventional EP & Pacing: Green
Owensboro, Ky River Heart Institute
15.) Neil Strathmore (1989-1991)Senior Fellow,Dept.Med.Univ.ofMelbourne, Aus. Melbourne
16.) Michael Gold (1990-1991)Prof.Medicine,Univ. Maryland;
Baltimore, Md. Director of EP & Pacing Univ. Maryland
17.) Bulent Zaim (1991-1992)Interventional Cardiologist: EP & Pacing
Istanbul, Turkey
18.) Marc Roelke (1992-1993)Director EP & Pacing St.Barnabas
Newark, N.J.Med.Ctr;Assoc Prof.Med. New Jersey College of Medicine and Dentistry
19.) Michael Sweeney (1993)EP & Pacing; Brigham and Womens
Boston, Mass. Hospital
20.) Jay Curwin (1993)EP Attending Morristown Memorial
Morristown, N.J. Hospital; New Jersey Coll. of Med.
21.) Marc Silver (1994-1995)Staff Cardiologist, Sanger Clinic
Charlotte, N.C. Director, EP & Pacing
22.) Ruth Kam (1995-1996) Senior Consultant Cardiologist,
Singapore National Univ. of Singapore
23.) David Barucha(1995-1996)EP and Pacing. Mt. Sinai Hosp. NYC
New York City
24.) Peter O'Callaghan (1996-1997)Director, EP & Pacing Cardiff Univ.
Cardiff, Wales Hosp. Cardiology Consultant Brit.
Health Service
25.) Adelqui Peralta (1996-1997)Director EP & Pacing Sanatorio Güemes
Buenos Aires, Arg. Buenos Aires, Argentina
26.) Michael Orlov(1998)Director, EP & Pacing; W. Roxbury
W. Roxbury, MassVA Hospital

27.) C.K. Krishnan(1998-1999)Sr. Staff Physician, Henry Ford Hospital
Cincinnati, Ohio & Case Western Reserve Univ.28.) Daniel Lustgarten (1999)Ass't. Prof.Med; Univ. Oklahoma
Oklahoma City, Okla. Currently Univ. of Vermont. Burlington, Vermont
Clinical Supervisory and Training Responsibilities
Within this group of trainees in pacing are Frederick Poulin, Director of Cardiology at the Mercy Hospital in Portland, Maine and recognized expert in pacing for northern New England; David Steinhaus, Originally Director of the Mid America Heart Institute in Kansas City and President and Director of NASPeXAM, (a subsidiary of NASPE that offers the international certification Examination of Special Competency in Pacing now completed by 2000 applicants) and now Vice President of Medtronic, Inc.; Andrew Eisenhauer, interventional catheterizer at the Brigham and Womens Hospital; Stanley Schneller, pacemaker and electrophysiology "guru" at Columbia Presbyterian Hospital in New York (and author of numerous monographs relating to pacing); Marc Schoenfeld, pacemaker and electrophysiology consultant in New Haven and past president of NASPE; Michael Gold, Director of Electrophysiology at the University of Maryland and frequent author and international speaker on topics relating to pacing for control of congestive heart failure; Marc Roelke, Director of Electrophysiology and Pacing at St. Barnabas Hospital and New Jersey College of Medicine in Newark and frequent author and speaker on topics relating to both fields; Neil Strathmore, Director of Pacing and Electrophysiology, Melbourne, Australia, frequent author, and speaker, and creator of the computer data storage program for pacemaker and arrhythmia device implantations at the Massachusetts General Hospital, and Southeast Asian member of the NASPeXAM Committee; Michael Sweeney, pacemaker and defibrillator device expert at Brigham and Womens Hospital; Ruth Kam, regional authority on pacing and electrophysiology in Singapore; Peter O'Callaghan, Director of Electrophysiology in Cardiff, Wales; Adelqui Peralta, Director of Electrophysiology and Pacing in Buenos, Aires, Argentina and presently Director, Electrophysiology at West Roxbury V.A. Hospital; Daniel Lustgarten, recent graduate of advanced electrophysiology training in ablation with Warren ("Sonny") Jackman and newly appointed to Burton Sobel's lab in Burlington, Vermont. Others who have entered private practice appointments around the world continue to serve as regional experts in pacing and its potential complications and management of same.
Year(s) Type of responsibility Level of Effort
Formally Supervised Trainees
Please see the foregoing list of past trainees in a separate Pacemaker and Arrhythmia Device laboratory of which I was director. More recently, and in anticipation of eventual retirement, I have merged my activities into the existing Electrophysiology Laboratory that is under the direction of Jeremy Ruskin. In this latter capacity, I have worked directly with each of that laboratory's trainees for the past 11 years with formal and informal lectures on the history and techniques of device prescription and implantation. This instruction has been provided both to the cardiology fellows and staff of that laboratory. I continue in this capacity spending one full day per week scrubbing in and performing device implantations with ongoing teaching of the cardiology fellow assigned to the individual cases of that day.
Formal Teaching of Peers (e.g., CME and other continuing education courses)
In my capacity as founder and past president of the professional society that is now know as The Heart Rhythm Society (HRS), I have participated in each and every one of the annual scientific meetings that have been held in various location in this country and Canada since the incorporation of the organization in 1979. This has involved giving formal lectures on specific topics of arrhythmia management as well as competition in educational debates on controversial subjects. The attendees of these individual teaching commitments is in the range of 500 to 1000 audience members.
Year(s) Title(s) or topic(s) or talks Number of talks in a single course
Course Name (Sponsor, if any) Location(s) (city or country)
Local Invited PresentationsReport of Teaching:
Hospital Based lectures (av. one hour each)
1-26-94Cardiology Grd. Rds.Current Status of Pacing1-19-95Cardiac Grand RoundsCurrent Trends in Pacing
Brigham and Womens Hosp.
5-11-95Medical Grd, Rds. MGHPacing for Brady Arrhythmias

11-8-95Cardiology Grd. Rds.Pacemakers: 1995

b. Orientation of Trainees and Staff:
4-18-94Cardiology FellowsBasics of Pacing I
6-6-94Cardiology FellowsBasics of Pacing II
7-27-94Cardiology FellowsBasics of Pacing III
11-2-94MGH Housestaff Big.8Management of Pacemakers8-2-95Cardiology FellowsBasics of Pacing
4-18-96Nuclear CardiologyPacemaker Function during ETT
7-10-96Cardiology FellowsBasics of Pacing
2-17-97Cardiology FellowsBasics of Pacing
7-10-97Cardiac Surgical StaffPacemaker Technology and function
7-16-97Cardiology FellowsOrientation lecture on pacing
3-19-98Cardiac Surgical StaffOrientation Lecture on pacing

7-15-98Cardiology FellowsOrientation lecture on pacing

8-10-98Electrophysiology StaffPacemakers: History
Perspective and
Current Indications
11-3-98Electrophysiology StaffPacing in the Treatment of Heart failure
2-1-19Electrophysiology StaffRate Responsive Pacing
9-29-00Electrophysiology StaffProgramming of pacers
c.) Graduate Medical Education:
10-16-95MGH Cardiology CourseCurrent Status of Pacing
10-9-97MGH Cardiology CourseCurrent Status of Pacing
10-22-98MGH Cardiology CourseCurrent Status of Pacing

d.) Attending Physician: (one month each)
11-1-94Ellison 10 (Stepdown)Cardiology Attending
Ellison 10 (Stepdown)Cardiology Attending
11-1-96Ellison 10 (Stepdown)Cardiology Attending
2-17-97Cardiology FellowsCardiology Attending
11-1-97Ellison 10 (Stepdown)Cardiology Attending
2-16-98Cardiology FellowsCardiology Attending
11-2-98Ellison 10 (Stepdown)Cardiology Attending
2-15-99Cardiology FellowsCardiology Attending
11-1-99Ellison 10 (Stepdown)Cardiology Attending
2-14-00Cardiology FellowsCardiology Attending

11-1-00Ellison 10 (Stepdown)Cardiology Attending
Report of Regional, National and International Invited Teaching and Presentations
Invited Presentations and Courses
Regional, National or International Contributions:
3-4-94Bowdoin CollegeAlumni Science Symposium
Brunswick, Maine"Living Better Electrically"
American College ofCardiology Abstracts
Cardiology Annual Meeting
Co-Chair:Oral Presentations
Chair:Clinical Tutorial:Management of Complex
NASPE Annual MeetingPacemaker Problems
Opryland, Tennessee
5-14-94NASPE Annual MeetingSub-mammary Pacemaker
Opryland, TennesseeImplant Technique
NASPE Annual MeetingManagement of Infected
Opryland, TennesseePacers & Defibrillators
6-15-94CARDIOSTIM MeetingCo-Chair & Speaker:RateNice, FranceResponsive Pacing
9-21-94NASPE Policy Conference:Pacemaker Re-use
Cleveland, Ohio
5-4-95NASPE Annual MeetingTechniques of Lead
Hynes Convention CenterExtraction

10-26-95World Congress on Pacing-Tutorial:Cardiac Pacing:
Buenos Aires, Argentina Ideal Device, pacing mode leads
World Congress on Pacing -Tutorial: Pacemakers & ICD surgery; new techniques, infections, and other complications

5-15-96NASPE Annual MeetingCo-Chair: New Techniques
Seattle, Wash'nin Device Implant and Lead Extraction
6-19-96Cardiostim: Nice, FranceChairman and speaker: Pacing for CHF: Techniques in evolution3-16-97ACC Annual Sci.MeetingChairman: Mini-course: Pacing
Anaheim, Calif.
3-18-97 ACC Annual Sci.MeetingFireside Panel:Practical Evaluation
and troubleshooting of pacemakers
5-8-97NASPE Annual Sci.MeetingChairman, Pacer Implant
Techniques & lead extraction
5-9-97NASPE Annual Sci.MeetingChairman: Changing Indicationsfor Cardiac Pacing
5-7-98NASPE Annual Sci.MeetingDebate: Controversies in Bradycardia: Multi-site &/orAlternative Site Pacing can Improve Hemodynamics: JWH Versus Claude Daubert of Rennes, France

6-19-98Cardiostim Meeting Poster: Undersensing in a Nice, FranceTransvenous ICD System: Hazard of pacing->VentricularFibrillation Peralta, Galvin,
Harthorne,et al
6-19-98Cardiostim MeetingChairman, Special Poster Nice, FranceSession:Electronic Article Surveillance & Pacemaker function
9-24-98FDA Advisory CommitteePresentation:Pacemakers and Bethesda, MarylandElectronic ArticleSurveillance Systems
10-7-98Berlin World ConferenceNew Technologies in Cardiac Berlin, Germany Pacing
11-18-98St. Vincents HospitalAnnual "Roger Robinson Testimonial Lecture":History of Pacing and
its Future Evolution
5-14-99NASPE Annual Sci.MeetingDebate: Automaticity in Pacemakers Precludes the Need for Routine Office Followup: JWH versus Seymour Furman
5-15-99NASPE Annual Sci.MeetingChair: Prolonging Survival in CHF Through Pacing
6-8-99American Association ofClinical Data on ElectronicMedical InstrumentationArticle Surveillance and
(AAMI) Annual Sci.MeetingMedical Devices from a
Boston. MassMedical Perspective
6-29-9911th World Congress on Expert Session: "The Cardiac Pacing & EPPacemaker Patient and the Berlin, GermanyRole of Electromagnetic Interference: MRI, CT, Diathermy, and Electrosurgical Equipment"
9-30-99San Diego Electrophys-The History of Cardiac
Physiology SocietyPacing
Mission Valley California
10-1-99Sharp Memorial HospitalLiving with Cardiac San Diego, CaliforniaArrhythmia Devices in an Electronically Hostile World
1-21-00Legislative Committee Witness: Review of inter-
New Hampshire Senateaction of cardiac arrhythmia
Devices with Electronic Article Surveillance Systems
3-12-00Am. Coll. CardiologyControversial Topics
Anaheim, Californiain Pacing (Chair)
5-18-00 North American Society Debate: Dual Chamber
Of Pacing and Electro-Pacing is unnecessary in the
Physiology (NASPE) majority of Patients:
Annual Scientific meetingProtagonist: Ronald Vlietstra
Washington, D.C.Antagonist: J.W. Harthorne
5-21-00  Bundesanstalt für Arbeits-Symposium:
Schutz und ArbeitsmedizinHerzschrittmacher und EAS
Berlin, GermanyAnlagen: Implications for
Cardiac Arrhythmia
Device Wearers – JWH
6-15-00Electromagnetic Field Chairman: Cardiostim
Emissions: ?? a hazard for Symposium: Nice, France
Cardiac Arrhythmia Device
10-20-2000Special Applications of National Physician Education
PacingSymposium: San Francisco, California

3-19-2001Concerted Action WorkshopInternational Commission on
Non-ionizing Radiation (ICNIRP) Munich, Germany
Witness concerning electronic
Article surveillance systems &
Cardiac arrhythmia devices
4-4-2001The Future of Implantable An Age of Innovation: New
Rhythm DevicesJersey College of Medicine
Newark Performing Arts Center
Report of Clinical Activities and Innovations
Current Licensure and CertificationLicensure and Certification:
YearType of License or Certification
1962Medical License, State of Maine (#5447)
1964Medical License, Commonwealth of Massachusetts (#28404)
1964American Boards of Internal Medicine (#22321)
1965Board Eligible, Subspecialty Board of Cardiovascular Disease
1986Examination of Special Competency in Cardiac Pacing (North American Society of Pacing and Electrophysiology - NASPeXAM) Certificate# 8
Practice ActivitiesClinical Practice: My cardiology practice includes the full spectrum of cardiac disease processes ranging from congenital heart disease in young adults to degenerative vascular disease in the aging. Many of these patients have implanted cardiac arrhythmia devices but approximately one quarter are individuals with general cardiac problems alone. Of the patients with cardiac arrhythmia devices, there are approximately 2000 currently being monitored via telephone telemetry and the majority of these receive their clinical care through my office.
Because of my long standing interest in and experience with complex device problems, I continue to see patients who have had deleterious or ineffective treatment elsewhere with implanted devices and who need expert analysis of a troubleshooting nature leading to appropriate revision or removal of errant devices. Approximately one half of the 300 plus patients who undergo pacemaker device related procedures in the MGH electrophysiology laboratory emanate from referral through my office.
The publications that I have introduced through many years can be divided into those that preceded 1974 when a dominant interest in cardiac catheterization and coronary disease led to the training of many individuals now prominent in cardiology in this country. During that earlier phase, a focus on diagnostic catheter techniques lead to a book chapter relating to this subject [ref C-4]. Dr. Robert Dinsmore and I introduced coronary angiography to the MGH in 1965 and performed the first several hundred coronary angiogram cases together as well as training several of the current MGH physicians who continue to perform these studies and contributed articles to the literature on coronary arterial anatomy [ref#E-8] and analysis of complications of contrast agent use [ref# A-7, A-8, A-24, A-25].
A shift in the direction of my interests arose in 1974 and lead to a career dominated by arrhythmia device therapy and the training of sub-specialty physicians in this area. This included a full year of individual training of approximately 30 cardiologists world wide in the specifics of pacemaker implantology and follow-up. A sequence of publications of our early experience with transvenous cardiac pacing and comparisons with the transthoracic approach were instrumental in delegating the latter method to the dustbin [A-9, A-10, A-12, A-13, A-14, A-15]. The technique of sub-mammary implantation of these devices in women for cosmetic benefit was refined here at the MGH Pacemaker Lab [A-45]. The early application of dual chamber cardiac pacemaker use at the MGH arose through my consulting experiences with several manufacturers and modifications of circuit design and lead design were one of the consequences. A local "Boston Pacemaker Club" was formed in Boston in 1974 and incorporated under a 501 C-3 tax exempt code as an educational organization to attract other physicians and engineers in the New England area who were involved in this specialty and in 1979, the North American Society of Pacing and Electrophysiology (NASPE) was formed and incorporated in Massachusetts under the leadership of the original four founding members (myself, Victor Parsonnet, Seymour Furman, Dryden Morse) [C-6]. I served as the president and organizer for the first two years and have continued as Treasurer and Chairman of its membership committee. This organization is now global with 5000+ members and over 50 countries represented. The national headquarters is in Washington, D.C. Annual Scientific Meetings of NASPE now attract in excess of 16,000 attendees with an annual budget in excess of six million dollars. This meeting was held in Denver in 2010.
List all clinical activities, both those at Harvard and its affiliates and those outside Harvard, and for each indicate:
Year(s) Type of activity Name and location of practice Level of activity
Clinical Innovations A childhood interest in model making, fly tying, piano playing and fly fishing led to a pragmatic application of associated techniques to the performance of arrhythmia device implantation that has included techniques for cosmetic device implantation by the sub-mammary route (publication A-45). Similar tunneling methodologies were employed in the initial defibrillator lead insertions and subsequent introduction of the non lead defibrillator now in development. So too, for female patients who have undergone double radical mastectomy, lead insertion via the external jugular vein with leads tunneled to an axillary pocket has save such women form the more invasive thoracotomy approach. Mechanical splicing techniques employed for repair of fractured pacing leads was commonplace with the original early lead designs and involved from methods similar to those used in the repair of fly rods. Much of the software that is employed in today's arrhythmia devices came about through collegial consulting arrangements with the Vitatron and Cordis pacing manufacturers which produced an understanding of the role of retrograde ventriculo-atrial conduction as it affected early pacer designs that were afflicted with pacemaker mediated tachycardias. The application of dual atrial pacing leads in patients who have undergone orthotopic cardiac transplantation to synchronize two functioning atrial signals through use of a double yoke connector was developed in the MGH lab.
Report of Education of Patients and Service to the Community
ActivitiesThe Boston Pacemaker Club was instigated in 1974 to provide physicians and surgeons with a common arena in which to exchange techniques and understanding of arrhythmia management. These quarterly lectures were usually held at the Boston Shriners Auditorium and the public were invited to participate. This effort to educate device recipients has been carried forward to the society originally known as NASPE and now designated The Heart Rhythm Society which offers a web site for the public to educate themselves on the specifics of device therapy as well as to search for acknowledged experts within their geographic area.
Educational Material for Patients and the Lay CommunityGroup materials (in print or other media) into three categories
Books, monographs, articles and presentations in other media
I have authored several stand alone books that reflect proceedings of various scientific meetings, prepared a video tape of surgical techniques of device placement, and created several thousand kodachrome, educational slides that depict anatomy, physiology, and mechanisms of device placement and complications. These have been pre-empted now by the introduction of Power Points visual aids and I am laboriously converted 45 years of lectures that utilize the foregoing visual aids into a computer based format.
Patient educational material
A variety of patient oriented educational booklets have been prepared and printed for distribution to device recipients with art work provided by the MGH medical art department. These have been updated over many decades to stay current with evolving technology and now address various aspects of arrhythmia management including pacemakers, defibrillators and ablative and medication techniques.
RecognitionSee above under Honors and Prizes: Because of my long association with arrhythmia management and device therapy including the education of several dozen "gurus" around the world, I have developed a reputation as the "go to" individual for complex arrhythmia management and analysis of device complications and a substantial proportion of my clinical activities continues to focus on these areas.
Report of Scholarship:
Include only manuscripts that are published or accepted for publication (forthcoming) in print or other media; do not include manuscripts that have been submitted but not accepted for publication or those that are in preparation; Please use bold-faced type for your name in the authorship list. Numbering of contributions should start with "1" in each new section.
A. Original Articles:
Sanders CA, Scannell JG, Harthorne JW, Austen WG. Severe mitral regurgitation secondary to ruptured chordae tendineae. Circulation 1965; 31:506.
Harthorne JW, Seltzer RA, Austen WG. Calcification of the left atrium. Review of the literature and proposed management. Circulation 1966; 34:198.
Sanders CA, Harthorne JW, DeSanctis RW, Austen WG. Tricuspid stenosis. A difficult diagnosis in the presence of atrial fibrillation. Circulation 1966; 33:26.
Dinsmore RE, Rourke J, Harthorne JW, DeSanctis RW, Austen WG. Angiographic findings in dissecting aneurysm of the aorta. N Engl J Med 1966; 275:1152.
Dinsmore RE, Sanders CA, Harthorne JW. Mitral regurgitation in idiopathic hypertrophic subaortic stenosis. N Engl J Med 1966; 275:1225.
Harthorne JW, Buckley MJ, Grover JW, Austen WG. Valve replacement during pregnancy. Ann Intern Med. 1967; 67:1032.
Smith RF, Harthorne JW, Sanders CA. Vectocardiographic changes during selective coronary artery injection. Circulation 1967; 36:63-76.
Smith, RF. Harthorne,JW, Sanders, CA Vectorcardiographic Changes During Intracoronary Injections; Dept of the Navy: Naval Aerospace Medical Institute: NAMI-995; 1967
Harthorne JW, Austen WG, Corning HC, McNamara JJ, Sanders CA. Technique and results of endocardial pacing in Complete Heart Block. Ann Intern Med 1967; 66:831.
Kastor JA, DeSanctis RW, Harthorne JW, Schwartz G. Transvenous Atrial pacing in the control of refractory ventricular irritability. American College of Physicians regional meeting (11/17/66), Montreal. Ann Intern Med. 1967; 66:939.
Sanders CA, Austen WG, Harthorne JW, Dinsmore RE, Scannell JG. Diagnosis and surgical treatment of mitral regurgitation secondary to ruptured chordae tendineae. N Engl J Med 1967; 276:943.
Harthorne JW, DeSanctis RW, Sulit YQM, Sanders CA, Austen WG. Epicardial versus endocardial pacemakers: analysis of 109 cases. Ann Thorac Surg 1968; 6:417.
Robboy SJ, Harthorne JW, Leinbach RC, Sanders CA, Austen WG. Autopsy findings with permanent pervenous pacemakers. Circulation 1969; 39:495.
Kastor JA, DeSanctis RW, Leinbach RC, Harthorne JW, Wolfson IN. Long term pervenous atrial pacing. Circulation 1969; 40:535.
Leinbach RC, Chamberlain DA, Kastor JA, Harthorne JW, Sanders CA. A comparison of the hemodynamic effects of ventricular and sequential atrio-ventricular pacing in patients with heart block. Am Heart J 1969; 78:502.
Kastor JA, Sanders CA, Leinbach RC, Harthorne JW. Factors influencing retrograde conduction: study of 30 patients during cardiac catheterization. Br Heart J 1969; 31:580.
Smith, R. F., Jackson, D.H., Harthorne, J.W., Sanders, C.A. Acquired Bundle Branch Block in the Naval Aviator Population; 1969: Naval Aerospace Medical Institute NAMI 1062:1-9
Mundth ED, Harthorne JW, Buckley MJ, Dinsmore RE, Austen WG. Direct coronary arterial revascularization for segmental occlusive disease. Surgery 1970; 67:168.
Smith RF, Jackson DH, Harthorne JW, Sanders CA. Acquired bundle branch block in a healthy population. Am Heart J 1970; 80:746.
Mundth ED, Harthorne JW, Buckley MJ, Dinsmore RE, Austen WG. Direct coronary arterial revascularization: treatment of cardiac failure associated with coronary artery disease. Arch Surg 1971; 103:529.
Mundth ED, Harthorne JW, Buckley MJ, Daggett WM, Austen WG. Direct coronary artery surgery for coronary artery occlusive disease. Am J Surg 1971; 121:478.Armstrong PW, Dinsmore RE, Harthorne JW, Sanders CA. Hemodynamic clues to the discrepancy between the angiographic and intra-operative assessment of aortic regurgitation. J Thorac Cardiovasc Surg 1973; 66:265.
Johnson RA, Hutter AM, DeSanctis RW, Yurchak PM, Leinbach RC, Harthorne JW. Chronic overdrive pacing in the control of refractory ventricular arrhythmias. Ann Intern Med 1974; 80:380.
Zir LM, Carvalho AC, Harthorne JW, Colman RW, Lees RS. Effect of contrast agents on platelet aggregation and C-serotonin release. N Engl J Med 1974; 291:134-5.
Caulfield JB, Zir LM, Harthorne JW. Blood calcium levels in the presence of arteriographic contrast material. Circulation 1975; 52:119-23.
Shubrooks SJ, Zir LM, Dinsmore RE, Harthorne JW. Left ventricular wall motion response to intravenous propranolol. Circulation 1975; 52:124-9.
Zir LM, Dinsmore RE, Goss C, Harthorne JW. Experience with preformed catheters for coronary angiography by the brachial approach. Cath Cardiovasc Diag 1975; 1:303-10.
Rubenstein JJ, Pohost GM, Dinsmore RE, Harthorne JW. The echocardiographic determination of mitral valve opening and closure: correlation with hemodynamic studies in man. Circulation 1975; 51.
Zir LM, Miller SW, Dinsmore RE, Gilbert JP, Harthorne JW. Interobserver variability in coronary angiography. Circulation 1976; 53:627.
Dash H, Johnson RA, Dinsmore RE, Harthorne JW. Cardiomyopathy syndrome due to coronary artery disease. I. Relationship to the angiographic extent of coronary disease and to remote myocardial infarction. Br Heart J 1977; 39.
Dash H, Johnson RA, Dinsmore RE, Francis CK, Harthorne JW. Cardiomyopathy syndrome due to coronary artery disease. II. Increased prevalence in patients with diabetes mellitus. A matched pair analysis. Br Heart J 1977; 39.
Zir LM, Dinsmore RE, Vezeridis M, Harthorne JW, Daggett WM. Effects of coronary artery bypass surgery on resting left ventricular function in patients studied one to two years following surgery. Am J Cardiol 1979; 44:601-6
Poulin FK, Harthorne JW. The cardiac pacemaker: functions, falterings, and fate. Geriatrics 1980; April:88-100.
Ruskin JN, Garan H, Poulin FK, Harthorne JW. Permanent radiofrequency ventricular pacing for management of drug-resistant ventricular tachycardia. Am J Cardiol 1980; 46:317-21.DiMarco JP, Garan H, Harthorne JW, Ruskin JN. Intracardiac electrophysiologic techniques in recurrent syncope of unknown cause. Ann Intern Med 1981; 95:542-8.
McEnany MT, Salzman EW, Mundth ED, DeSanctis RW, Harthorne JW, Weintraub RM, Gates S, Austen WG. The effect of antithrombotic therapy on patency rates of saphenous vein coronary artery bypass graft. J Thorac Cardiovasc Surg 1982; 83:81-89.
Boucher, C.A., Pohost, G.M., Okada, R.D., Levine, F.H., Strauss, H.W., Harthorne, J.W. Effect of Ventricular Pacing on Left Ventricular Function Assessed by Radionuclide Angiography Am. Heart Journal 1983:106:1105-1111
Stewart WJ, DiCola VC, Harthorne JW, Gillam LD, Weyman AE. Doppler ultrasound measurement of cardiac output in patients with physiologic pacemakers: effects of left ventricular function and retrograde ventriculoatrial conduction. Am J Cardiol 1984; 54:308.Harthorne JW, Eisenhauer AC, Steinhaus D, Pacemaker mediated tachycardias: an unresolved problem. PACE 1984; 7:1140-1147.
Eagle KA, Mulley AG, Singer DE, Schoenfeld D, Harthorne JW, Thibault GE. A formal cost comparison of single chamber and dual chamber pacemakers. Ann Intern Med 1986; 105:264-271.
Salahi F, Systrom DM, DiCola V, Boucher C, Hand R, Kanarek D, Harthorne JW. Cardiopulmonary exercise testing in DDD compared to VVI pacing modes. Am J Noninvas Cardiol 1987; 1:244-250.
Rediker DE, Eagle KA, Homma S, Gillam L, Harthorne JW. Clinical and hemodynamic comparison of VVI versus DDD pacing in patients with DDD pacemakers. Am J Cardiol 1988; 61:323-329.Kelly, P.A., Cannom D.S., Garan, H., Mirabel, G., Harthorne, J.W., Hurvitz, R., Vlahakas, G., Jacobs, M., Ilvento, J., Buckley, M.J., Ruskin, J. The automatic implantable cardioverter-defibrillator(AICD): efficacy, complications, and survival in patients with malignant ventricular arrhythmias J. Am. Coll. Of Cardiology 1988: 11:1278-1286
Roelke, M., McNamara, D., Osswald, S.S., Semigran, M., Dec, W. and Harthorne, J.W. A comparison of VVIR and DDDR pacing following cardiac transplantation PACE 17:2047:1994
Roelke, M., Jackson, G., Harthorne, J.Warren Submammary Pacemaker Implantation: A Unique Tunneling Technique PACE: 1994; 17:1793-1796
Roelke, M., O'Nunain, S.S., Garan, H., Harthorne, J.W. et al Ventricular pacing induced ventricular tachycardia in patients with implantable cardioverter defibrillators PACE 18:486-491:1995
Roelke, M., O'Nunain,S.S., Osswald. S., Garan, H., Harthorne, J.W., Ruskin, J.N.Subclavian crush syndrome complicating transvenous cardioverter-defibrillator systems PACE 18:973-979:1995
Kam, R.L., Garan, H., McGovern, B., Ruskin, J.N., and Harthorne, J.W. Transient right bundle branch block causing R wave attenuation post defibrillation PACE 20: 1997:130-131
49.Singh, Jagmeet, Heist, E., Ruskin, Jeremy, Harthorne, J.W. Dialing in Cardiac Re-synchronization therapy: Overcoming constraints of the coronary venous anatomy in Journal of Interventional Cardiac Electrophysiology 17:51-58 2006
B. Proceedings of Meetings:
Harthorne JW, Williams C, Bland EF. The post-pericardiotomy and related syndromes. The Heart and Circulation. Second National Conference on Cardiovascular Diseases. 1964; 1:513.
Harthorne JW, Smith R, Sanders CA. Vectocardiographic changes during selective coronary angiography. Aktuelle Probleme der Vektorkardiographie, VIII. Internationales Kolloquium fur Vektokardiographie, Wien, September 1967 (published June 1968).
Harthorne, J. Warren, Leinbach, R.C., Sanders, C.A., Austen, W.G. Clinical Results of Transvenous Pacing Annals of the N.Y. Academy of Sciences 1969; Vol. 167; no.2;
pgs. 1008-1015
McEnany T, Harthorne JW, Mundth ED, Weintraub RM. A controlled clinical trial of antithrombotic therapy in patients undergoing aortocoronary artery bypass grafting. Vth Congress of the International Society on Thrombosis and Haemostasis, Paris, July
Boucher, CA, Pohost, GM, Poulin, FK, Okada, RF, Strauss, HW, Harthorne, JW Use of Radionuclide Angiography to Assess Alterations in Ventricular Performance at Rest and Exercise During Ventricular Pacing in Proceedings of the VIth World Symposium on Cardiac Pacing PACESYMP 1979 Chapter 13-5
Harthorne JW, Parsonnet V. Task Force VI: Training in Cardiac Pacing. JACC 1986; 7(6):1213-1214.
Harthorne JW and Parsonnet VP. Physician Competence to Perform Cardiac Pacemaker Insertions (1992), Task Force on Cardiac Pacing ACP, AHA, ACC Task Force Statement on Clinical Privileges in Cardiology (in press).
Kurnik PB, Cywinski JK, Zir LM, Newell JB, Harthorne JW. Frequency and amplitude analysis of endocardial electrograms; implications for demand pacemaker design. Proceedings of the International Conference on Biomedical Transducers. Additif aux
Actes du Colloque Biocapt 75. (Paris) November 1975:A1.9, 3-10. Harthorne JW. Prognostic determinants of late survival in patients with cardiac pacemakers.   Vth International Symposium on Cardiac Pacing, Tokyo, Japan.
March 1976. Acta Med Scand.Harthorne JW. Indications for various types of cardiac pacemakers. In: Harthorne JW, Thalen     HJ, eds. Proceedings of the Boston Colloquium on Cardiac Pacing. The Hague: Martinus           Nijhoff, 1977: pp 35-46.
Harthorne JW. Differential diagnosis of pacemaker system malfunction. In: Harthorne JW,       Thalen HJ, eds. Proceedings of the Boston Colloquium on Cardiac Pacing. The Hague: Martinus       Nijhoff, 1977: pp 123-143.
Harthorne, J.W. Chairman: Round Table Discussion: Proceedings of the Boston Colloquium on       Cardiac Pacing The Hague; Martinus Nijhoff 1977 pages 161-178
Harthorne JW, McDermott J, Peterson K. Who should implant a pacemaker system--cardiologist or surgeon? Proceedings of the Brussels Symposium on Cardiac Pacing.
The Hague: Martinus Nijhoff, 1978: 263-70.
Harthorne, J.W. Pacemakers, Technological Advances and Recognition of Pacemaker Failure;       Proceedings of the Hong Kong Cardiological Society 1978: Vol. 5: 73-85
Harthorne JW. What next? In: Proceedings of the First European Symposium on Cardiac       Pacing. The Hague: Martinus Nijhoff 1978Ruskin JN, Garan H, Poulin FK, Harthorne JW. Patient activated radiofrequency pacing for recurrent sustained ventricular tachycardia. Proceedings of the VIth World
Symposium on Cardiac Pacing (Montreal) (publisher/Pacesymp) 1979; Chapter 6-8.Harthorne JW. Types of pacing. Lectures by visitors from abroad, Chinese Medical Association, Shanghai Branch. Presented on lecture tour of the Peoples Republic of
China. Chinese Cardiology Journal: February 1980:pp 23-25
Harthorne JW. Temporary pacing. Lectures by visitors from abroad, Chinese Medical Association, Shanghai Branch. Presented on lecture tour of the Peoples Republic of
China. Chinese Cardiology Journal: February 1980: pp 26-29
Harthorne JW. Complications of cardiac pacing. Lectures by visitors from abroad, Chinese       Medical Association, Shanghai Branch. Presented on lecture tour of the Peoples Republic of       China. Chinese Cardiology Journal: February 1980: pp 34-37.
Harthorne JW. Clinical evaluation of patient with valvular disease. Lectures by visitors from abroad, Chinese Medical Association, Shanghai Branch. Presented on lecture tour
of Peoples Republic of China. Chinese Cardiology Journal: February 1980: pp 37-38.
DiCola VC, Stewart WJ, Harthorne JW, Weyman AE: Doppler ultrasound
measurement of cardiac output in patients with physiologic dual chamber
pacemakers. Proceedings of the VII World Symposium on Cardiac Pacing.
Nachdruck aus: Cardiac Pacing 1983; 231-239. Steinkopff Verlag Darmstadt.
Furman, S., Hauser, R., Harthorne, J. W., Hueter, D.C., Griffin, J.C., Bilitch, M.,
Goldman, B., Najafi, H., Katz, S.H., Brown, M.D., Rahmoeller, G.A., Resources
Required for Pacemaker Implantation NASPE Policy conference edited by
R. Hauser 1983 PACE 6:139-155
Harthorne, J.W. Future Directions in Cardiac Pacing: Training and Certification;in Proceedings of the Vth Asian Pacific Symposium on Cardiac Pacing and
Electrophysiology Makuhari, JAPAN 1993: pp 5-6
C. Reviews, Chapters, and Editorials:
Zir LM, DeSanctis RW, Harthorne JW. Diagnostic uses of electrical pacing.
Diag Meth Cardiol 1975:401-14.
Harthorne JW, Pohost GM. Electrical therapy of cardiac dysrhythmias. In: Levine HJ, ed.       Clinical Cardiovascular Physiology. New York: Grune and Stratton. 1976; 853-882
Harthorne JW. Selection of various types of cardiac pacemakers. In: Norman J,
Rickards A, eds. Proceedings of the Pacemaker Colloquium. The Netherlands: Vitatron Medical 1976.
Harthorne JW, Sanders CA. Cardiac Catheterization. In: Willerson J, Sanders CA, eds. Clinical Cardiology. New York: Grune and Stratton. 1977.
Harthorne JW. Indications for various types of cardiac pacemakers. In: Chung EK, ed. Artificial Cardiac Pacing: Practical Approach. New York: Williams and Wilkins, 1978:252-260.
Harthorne JW, Bilitch M, Furman S, Goldman B, MacGregor D, Morse D, Parsonnet V. The North American Society of Pacing and Electrophysiology Editorial. PACE 1979:pp 521-522
Eagle KA, Harthorne JW. Single and dual chamber pacing compared. Cardiology
Board Review 5:11 Nov. 1988 pp. 89-99.
Harthorne JW: Programmable pacemakers: Technical features and clinical applications
in pacemaker therapy. Leonard S. Dreifus, ed. Cardiovascular Clinics. Philadelphia:
F.A. Davis Co. 1983: 135-147.
Harthorne JW, McDermott J, Poulin FK. Cardiac Pacing. In: Johnson RA, Haber E, Austen       WG, eds., The Practice of Cardiology. Boston: Little, Brown and Co. 1980: pp 219-261
Harthorne JW. Historic milestones of electrotherapy and cardiac pacing. Prog Cardiovasc Dis       1981; 23:389-392.
Harthorne JW. Indications for pacemakers. Prog Cardiovasc Dis 1981; 23:393-400.
Steinhaus D, Harthorne JW. Anatomy of the cardiac conduction system. Intell Rep Cardiac       Pacing Electrophysiol (IRCPE) 1982; 1:1.
DiCola VC, Harthorne JW: Physiologic pacing. Ann Rev Med 1984; 35:493-502.
Steinhaus DM, Harthorne JW: Pacemakers: understanding and avoiding malfunction. J Cardiovasc Dis 1983; 8:771-780.
Parsonnet V, Escher DJW, Furman S, Harthorne JW, et al. Indications for
dual-chamber pacing. PACE 1984; 7:318-319.
DiCola, V.,C., Harthorne JW. Different modes of cardiac pacing. In: Chung EK, ed. Artificial Cardiac Pacing. Baltimore: Williams and Wilkins, Second Edition
1984: 247-255.Harthorne JW. Pacemaker leads: editorial review. Intl J Cardiol 1984; 6:423-429.
Harthorne, J. Warren The Physiology of Cardiac Pacing in Intelligence Reports in Cardiac       Pacing and Electrophysiology vol 3 number 2 December 1984:1-5
Harthorne, J. Warren Follow-up of the Patient with a DDD Pacemaker in Intelligence Reports on       Cardiac Pacing Vol 3 number 3 March 1985:1-5
Harthorne JW. The future of Cardiac pacing. In: Barold SS, ed. Modern Cardiac
pacing. Mount Kisco: Futura Publishing Co., 1985. pp 949-958
Schneller S, Harthorne JW. Carotid sinus hypersensitivity. Clin Prog in Electrophysiol and       Pacing 1985; 3(6):389-402.
Harthorne JW. How to choose a cardiac pacing system (editorial). Cardiovascular Medicine Vol. 11, No. 1, 1986
Harthorne JW. Cardiac Pacing, In: Tsung O. Cheng, M.D., ed., The International
Practice of Cardiology, Pergamon Press, 1986; pp. 377-393.
Harthorne JW. Current Problems in Cardiology: Cardiac Pacemakers 12(11):649-693. Year       Book Medical Publishers 1987.
Harthorne JW. Cardiac Pacing, In: Current Therapy in Cardiothoracic Surgery, G. Vlahakas ed., B.C. Decker Inc., Ontario, Canada 1989: 324- 329.
Harthorne JW, Jansyn E. Pacemaker Mediated Tachycardia: An Unsolvable Problem,
In: New Perspectives in Cardiac Pacing, S. Barold and J. Mugica, eds., Futura Publishing Co., Mt.             Kisco, N.Y. 1988: 387-403.
Eagle KA, Harthorne JW. Single chamber and dual chamber pacing compared. Cardiology       Board Review 1988; 5(11): 88-99.
Harthorne JW, Eisenhower A, Steinhaus DM. Cardiac Pacing, In: The Practice of Cardiology, Eagle KA, Haber E, DeSanctis RW, Austen WG, (eds.), Little, Brown and
Co., 1989, pp. 287-336.
Harthorne JW, Strathmore N. DDD versus VVIR pacing: Physiologic option versus convenient excuse 1991 S. Barold and J. Mugica (eds.), in New Perspectives in Cardiac Pacing       2; Futura Press pp 313-324 .
Harthorne JW, Strathmore NF. Stimulation DDD contre stimulation VVIR, l'option physiologique contre la solution de facilité, In: Jacques Mugica, M.D., S. Serge Barold, M.D.       and Alain Ripart, M.D., eds., La Stimulation Cardiaque, Masson, Paris, 1992: pp. 280-288.
Schoenfeld, M., Harthorne, J.W., Pacemaker Programmers, Kenneth A. Ellenbogen, G. Neal Kay and Bruce Wilkoff eds in Clinical Cardiac Pacing W.B. Saunders publisher 1994
Roelke, M., Harthorne, J.W. Pacing for Bradyarrhythmias in P.J. Podrid and P.R.
Kowey eds Cardiac Arrhythmias: Mechanism, Diagnosis, and Management Williams
and Wilkins 1994
Harthorne, J.W. and Barold, S.S. Atherosclerosis, the Conduction System and Cardiac Pacing       in Fuster, V., Ross, R., Topol, E. eds Atherosclerosis and Coronary Artery
Disease Lippincott-Raven Publishers 1996: 1013-1030
Harthorne J.W. Theft Deterrent Systems: ? a Threat to medical device recipients or an industrial "cat fight" Editorial PACE 21: 1998 PP 1845
Harthorne JW: New England Journal of Medicine: Letter to the Editor: Implantable Defibrillators, Pacemakers, and Electronic Article Surveillance Devices 340: 1999: 1116
Harthorne, J.W. Commentary: Sagging Body Parts PACE 22: 1999: pp 375
Harthorne, J.W. Commentary: Commemorating 30 Years of Medical Publishing;
Futura Publishing Company, Inc. 2000
Harthorne, J.W. Effects of Physiologic Pacing versus Ventricular Pacing: Letter to the Editor       NEJM 343: 2000: 1417
Harthorne, J.W. Electronic Article Surveillance Systems and Cardiac Arrhythmia
Devices Cardiology in Review Vol 9; No. 1 January 2001
Harthorne, J.W., Mugica, J., Sutton, R., Groh, W. The Effects of Anti-shoplifting
Systems on Pacemakers and Defibrillators CVR & R, 1998, 10-25-34
Harthorne, J.W. A Stretched Thin Doctor Draws the Line: "Dear Mrs. Pennywasher" PACE       24:2001:pp 111
Abelmann, W.H., Axelrod, P., Cohen, S.I., Freedberg, A.S., Harthorne, J.W. Faculty of Medicine – Memorial Minute: Paul M. Zoll Harvard University Gazette April 19, 2001 page 12
Harthorne, J.W. Musings: "The Grate" PACE: 2001 (in press)
Suri, R., Harthorne, J.W. Galvin, J. Automatically Optimizing Pacing Output: An
Excellent Idea, but with Potentially Lethal Pitfalls PACE 24: 2001: pp 520-523
D. Books, Monographs, Textbooks:
1.Harthorne JW, Thalen HJTh (editors). Boston Colloquium on Cardiac Pacing. The Hague: Martinus Nijhoff Medical Division, 1977.
2.Thalen HJTh, Harthorne JW. Proceedings of the Brussels Symposium on Cardiac Pacing. The Hague: Martinus Nijhoff Medical Division, 1978.
3. Thalen, HJTH. Harthorne, JW: eds, To Pace or Not to Pace:Controversial Subjects on Cardiac             Pacing. The Hague / Boston Martinus Nijhoff Medical Division, 1978
E. Clinical Communications:
Harthorne JW, Marcus AM, Kaye M. Management of massive imipramine overdosage with mannitol and artificial dialysis. N Engl J Med. 1963; 268:3.
Dinsmore RE, Sanders CA, Harthorne JW, Austen WG. Congenital pulmonary stenosis with calcification. Radiology 1966; 87:429.
Dinsmore RE, Sanders CA, Harthorne JW, Austen WG. Calcification of the
congenitally stenotic pulmonary valve. N Engl J Med 1966; 275:99
Kumar S, Harthorne JW, Dinsmore RE, Sanders CA. Opacification of the right heart as
a complication of the left ventricular angiography. Am J Cardiol. 1967; 20:133.Harthorne JW, Kantrowitz PA, Dinsmore RE, Sanders CA. Traumatic myocardial infarction. Report of a case with normal coronary angiogram. Ann Intern Med 1967; 66:341.
Shine KI, O'Keefe D, Harthorne JW. Arteriovenous fistula following retrograde
brachial catheterization. N Engl J Med 1967; 276:1431.
Leinbach RC, Harthorne JW, Dinsmore RE. Straight back syndrome with pulmonary venous       obstruction. Am J Cardiol 1968; 21:588.Harthorne JW, Dinsmore RE. Selective coronary angiography. Heart Bull. 1969; 18:6.
Harthorne JW, Dinsmore RE. Indications for coronary angiography. MGH Laboratory Newsletter. 1973; volume 6; number 3.
Harthorne JW. Case records of the Massachusetts General Hospital (22). Cardiomyopathy in a young man with pulmonary sarcoidosis. N Engl J Med 1975; 293:1138.
Kronmal RA, Davis KB, Fisher LD, Jones RA, Gillespie MJ.(J.W.Harthorne, Principal Investigator at MGH) Data management for a large collaborative clinical trial (CASS--Coronary Artery Surgery Study) in computers. Biomed Res 1978; 11:6.
Harthorne JW, Scully RE. Shaking chills, fever and sudden death 13 days after acute myocardial infarction. New Engl J Med Case 27-1970;vol. 282:1477-1485.
Harthorne JW, Scannell JG, Dinsmore RE. Anomalous origin of the left coronary artery from the pulmonary artery. A remediable cause of sudden death in adults. N Engl J
Med 1966; 275:660.
Harthorne JW, Dinsmore RE, DeSanctis RW. Superior vena caval anomaly preventing pervenous pacemaker implantation. Br Heart J 1969; 31:809
Harthorne JW, Trelstad RL. Multiple aortic aneurysms and increasing aortic insufficiency. N       Engl J Med Case 21-1971; vol.284:1201-1210.
Harthorne JW. Chills and fever after acute myocardial infarction. In: Castleman B, DeSanctis RW, eds. Cardiac Clinicopathological Conferences of the Massachusetts General       Hospital. Boston: Little, Brown and Company. 1972.
Harthorne JW. Preliminary experience with the Starr-Edwards and Cordis Omnicor pacemaker systems. IVth International Symposium on Cardiac Pacing, Groningen, The Netherlands. Cardiac Pacing. Van Gorcum Press. 1973:349.
Liberthson RS, Barron K, Harthorne JW, Dinsmore RE, Daggett WM. Traumatic coronary       arterial fistula: a case report and review of the literature. Am Heart J 1973; December:817.
Harthorne JW. Case records of the Massachusetts General Hospital (24). New murmur after       aortic valve replacement. N Engl J Med 1973; 288:1290-7.
Harthorne JW. Case records of the Massachusetts General Hospital (42). Cardiac
failure after a coronary artery bypass operation. N Engl J Med 1974; 291:896-903.
Liberthson RR, Dinsmore RE, Bharti S, Rubenstein JJ, Caulfield J, Wheeler EO, Harthorne JW,       Lev M. Aberrant coronary artery origin from the aorta. Circulation 1974; 50:774-9
Harthorne JW. Case records of the Massachusetts General Hospital (27). Progressive congestive heart failure one year after mitral valve replacement. N Engl J Med 1977; 297:37.
McDermott J, Harthorne JW. Current technology of cardiac pacemakers. Prim Cardiol 1978;       Vol. 4: No 7:34-39, Part I
McDermott J, Harthorne JW. Current technology of cardiac pacemakers. Prim Cardiol 1978;       Vol. 4: No 8:52-55, Part II
Dodinot B, Harthorne JW, Kormann DS, Parsonnet V. Professional qualifications for pacemaker implantation (panel discussion). PACE 1978; 1:381-6.
Harthorne JW. Following the pacemaker patient at Massachusetts General Hospital. Soderlind B, ed. Impulse, Cardiac Pacemakers, Inc. 1979, volume 13.
Harthorne JW. Living better electrically. American Heart Association News Release/Living       with Your Heart series 1979.
Weiner DA, Ryan TJ, McCabe CH, Kennedy JW, Schloss M, Tristani F, Chaitman BR, Fisher       LD. Exercise stress testing: correlations among history of angina, ST-segment response and       prevalence of coronary artery disease in the coronary artery surgery study (CASS) (Harthorne       JW, principal investigator MGH). N Engl J Med 1979; 301:230-5.
CASS Principal Investigators and Their Associates Coronary Artery Surgical Study (CASS) A       Randomized Trial of Coronary Artery Bypass Surgery: Quality of Life in Patients Randomly       Assigned to Treatment Groups (Harthorne, J.W. Principle Investigator – MGH) Circulation 68:       no 5; 951-960; 1983
CASS Principal Investigators and Their Associates Coronary Artery Surgical Study (CASS) A       Randomized Trial of Coronary Artery Bypass Surgery: Survival Data (Harthorne, J.W. Principle       Investigator – MGH) Circulation 68; No. 5; 939-950 1983
CASS Principal Investigators and Their Associates Myocardial Infarction and Mortality
in the Coronary Artery Surgery Study (CASS) Randomized Trial (Harthorne, J.W. Principal Investigator – MGH) N.E.J.M. 1984; 310:750-7
Harthorne, J. Warren Letter to the Editor: The Missing Pacemaker: A Suicidal
Attempt PACE 1980: 3:740-741
Harthorne JW.. Sudden death in a patient with complete heart block. N Engl J Med
Case 1-1982; 306:32-39.
Harthorne JW: Hilbert Thalen: Obituary. International J Cardiol 1983; Vol 3 #1: pp 125-128.
Harthorne JW. Introduction to pacemaker troubleshooting. Part I Medtronic News.
June, 1983: pp 3-10.
Harthorne, JW. Introduction to Pacemaker Troubleshooting Part II Medtronic News September 1983: pp 9-15
Harthorne JW, DiCola VC: Grommet malfunction. PACE 1983; 6:655-6.
Harthorne JW: Present to conference: Consultation patient KC. Clinical Progress in Pacing and       Electrophysiology 1983; Vols 1 and 2:193-94.
Eisenhauer AC, Harthorne JW. Pacemaker therapy following cardiac surgery.
Medtronic Case Studies MC 832339-1. Medtronic Inc., March 1984.
Rediker DE, Harthorne JW. Symptomatic bradycardia: How to select the appropriate pacemaker. Cardiac Impulse July 1987; 8(4): 1-7
41.Harthorne, J. Warren Musings: The Grate PACE 25:no 3: 361 March 2002
42.Harthorne, J. Warren, Palacios, Igor A Medical Mystery NEJM vol 346:no 24:1828 June 13th 2002
43.Harthorne, J. Warren Obituary: Seymour Furman Heart Rhythm Journal April 2006
44. Harthorne, J. WarrenObituary: Seymour Furman PACE May 2006

F.Educational Materials: Course Syllabi:
Multiple syllabi have been prepared over many years for post graduate courses in Cardiology (MGH), American College of Cardiology (Heart House), MGH House Staff Lectures, and Certification examination questions for NASPeXAM but it is impractical to include them here.
H. Non Print Materials :Films:
1.Harthorne JW. Indications for Pacemaker Insertion and Technique of Follow-up. Network for Continuing Medical Education. Thirty-minute review of the present "state of the art" for internists and family practitioners. July 1979.
2."You and Your Pacemaker." Produced by the Massachusetts General Hospital Television Studio through an educational grant from Medtronic, Ind. A 30-minute review of pacemaker technology, function and self-monitoring technique of pacemaker recipients.3.Harthorne JW, Griffin J, Swan J. Update on Cardiac Pacing, Lifetime T.V. Channel, Cardiology Update (30 minutes), October 30, 1988.
4.NASPE Video Library: Transvenous Temporary Cardiac Pacing, J.W. Harthorne (ed.), Park Rowe Publishers, 1990.
Sanders CA, Harthorne JW, Heitman H, Laver MB. Introduction by Haber E. Effect of vasopressor administration on blood gas exchange in mitral disease. Am Fed Clin Res
Proc 1965; 8:351.
Seltzer RA, Harthorne JW, Austen WG. The appearance and significance of left atrial calcification (exhibit). American Roentgen Ray Society, Washington, 1965. AJR 1967; volume       C, number 2:302.
Harthorne JW, Austen WG, Corning HC, McNamara JJ, Sanders CA. Technique and results of       endocardial pacing in the elderly patient. Circulation 34:124 (suppl) (abstract).
Harthorne JW, DeSanctis RW, Sulit YQM, Sanders CA, Austen WG. Endocardial
versus epicardial pacing. Analysis of 100 cases. Circulation 1967; 36(Suppl II):134.
Leinbach RC, Harthorne JW, Kastor JA, Sanders CA. Newer pacemakers and the electrocardiogram. Circulation 1967.
DeSanctis RW, Kastor JA, Leinbach RC, Harthorne JW. Long-term pervenous atrial pacing.       Circulation 1968; (Suppl VI):65.
Dinsmore RE, Harthorne JW, Sanders CA. Roentgenographic findings in pacemaker failure.       Circulation 1968; (Suppl VI):66.
Harthorne JW, Leinbach RC, Sanders CA, DeSanctis RW, Austen WG. Permanent endocardial pacing. Circulation 1968; (Suppl VI):96.
Leinbach RC, Chamberlain DA, Kastor JA, Harthorne JW, Sanders CA.
Atrioventricular pacing in heart block. Circulation 1968; (Suppl VI):125.
Robboy SJ, Harthorne JW, Leinbach RC, Sanders CA, Austen WG. Autopsy findings with       permanent pervenous pacemakers. Circulation 1968; (Suppl VI):164.
Mundth ED, Harthorne JW, Buckley MJ, Austen WG. Direct coronary arterial revascularization for segmental occlusive disease. Presented at the Society of Vascular Surgery,       23rd Annual Meeting, July 1969.
Kastor JA, Harthorne JW. Types of cardiac pacing--a clinical survey. Proceedings
of the 8th International Conference on Medical and Biological Engineering 1969:291.
Mundth EM, Harthorne JW, Buckley MJ, Daggett WM, Austen WG. Direct coronary artery       surgery for coronary artery occlusive disease. Presented at the 51st Annual
Meeting of the New England Surgical Society, October 1-3, 1970.
Leinbach RC, Mundth ED, Dinsmore RE, Harthorne JW, Buckley MJ, Kantrowitz A, Austen       WG, Sanders CA. Selective coronary and left ventricular cineangiography during intra-aortic       balloon assist for cardiogenic shock. Am J Cardiol 1970; 26:644.
Harthorne JW, Armstrong PW, Mundth ED, Dinsmore RE. The effect of nitroglycerin
on demonstration of coronary collateral circulation. American Heart Association
Abstracts, 43rd Scientific Sessions, 24rd Annual Meeting, Council on Arteriosclerosis, Laennec             Cardiovascular Sound Society. Circulation 1970; 42:612.
Dinsmore RE, Armstrong PW, Harthorne JW, Kimerling L, Sanders CA. The effect of length       and multiplicity of stenoses in coronary artery disease: a mathematical approach. Circulation       1971; 14(Suppl II):594.
Johnson RA, Hutter AM, DeSanctis RW, Yurchak PM, Leinbach RC, Harthorne JW. Chronic       overdrive pacing in the control of refractory ventricular arrhythmias. Circulation 1972; 16(Suppl       II):431.
Rubenstein JJ, Pohost GM, Dinsmore RE, Harthorne JW. The echocardiographic determination of mitral valve opening and closure. Circulation 1973; 48(Suppl IV).
Zir LM, Dinsmore RE, Pohost GM, Harthorne JW. Effect of nitroglycerin on left ventricular function in patients with coronary artery disease. Circulation 1973; 48(Suppl IV):233.
Caulfield JB, Zir LM, Harthorne JW. Electro mechanical dissociation during coronary angiography. Circulation 1974; 50(Suppl III):53.
Dash H, Johnson RA, Dinsmore RE, Francis CK, Harthorne JW. Syndromes of coronary artery       disease in diabetics and non-diabetics. Circulation 1974;
50(Suppl III):109.
Thalen H, Harthorne JW, Oude Luttinkhuis HA, Bredee JJ, Hardjowijonno R. A new transvenous electrode, its development and clinical evaluation. Vth International Symposium on       Cardiac Pacing. March 1976.
Harthorne JW. Prognostic determinants of late survival of patients with cardiac pacemakers. Vth International Symposium on Cardiac Pacing, Tokyo, Japan.
March 1976, Excerpta Medica Amsterdam.Miller SW, Zir LM, Goss CG, Harthorne JW, Dinsmore RE. Image quality in coronary angiography; influence on interobserver variability, 49th Scientific Session, November 1976.
McEnany MT, DeSanctis RW, Harthorne JW, Mundth ED, Weintraub W, Austen WG, Salzman       EW. Effect of anti-thrombotic therapy on aortocoronary vein graft patency
rates. 49th Scientific Session, November 1976.
Harthorne JW. Indications for the applications of cardiac pacemakers devices. Seventh European Congress of Cardiology, June 1976.
Zir LM, Miller SW, Goss C, Harthorne JW, Dinsmore RE. Interobserver variability in coronary       angiography. 26th American College of Cardiology Meeting, March 1977.
Ruskin JN, Garan H, Poulin FK, Harthorne JW. Patient activated radiofrequency pacing for       sustained ventricular tachycardia. PACE 1979; 5:A-12.
Boucher CA, Pohost GM, Poulin FK, Strauss HW, Okada RD, Harthorne JW. Radionuclide       angiographic evaluation of left ventricular performance during ventricular pacing. Am J Cardiol       1980; 45:458.Poulin FK, Harthorne JW. Initial experience with an A-V sequential pacemaker having "committed" ventricular stimulation. Second International Symposium on Cardiac
Pacing, Florence, Italy, May 1981.
Dimarco, J.P., Garan, H., Harthorne, J.W., Ruskin, J.N. Unexplained Syncope: Results
of therapy based on electrophysiologic study Am. J. Cardiol 1981:47: 433
DiCola VC, Hand R, Boucher CA, Kanarek DJ, Okada R, Pohost GM, Harthorne JW. Exercise       cardiopulmonary assessment with dual chamber vs ventricular pacing. North American       Society of Pacing and Electrophysiology, Annual Meeting, New Orleans,
March 1983, PACE 1983; 6:311.
DiCola VC, Hand R, Boucher CA, Kanerek DJ, Okada R, Pohost GM, Harthorne JW. Exercise       cardiopulmonary assessment with dual chamber vs ventricular pacing. VII
World Congress of Cardiac Pacing. Vienna, Austria, May 1983. PACE 1983; 6:A-81, #300.
Boucher CA, Pohost GM, Okada RD, Levine FH, Strauss HW, Harthorne JW. Effect of ventricular pacing on left ventricular function assessed by radionuclide angiography. Am Heart J 1983; 5:1105-1111.
Roelke, M., Trouton,T.G., O'Nunain, S.S., Garan, H.G., Harthorne, J.W., Ruskin, J.N.
The need for permanent pacemaker implantation following slow atrioventricular nodal
and accessory pathway radiofrequency ablation J. Am. Coll. Cardiology 1993; 21 (2)
Roelke, M., O'Nunain, S.S., Osswad, S., Garan, H., Harthorne, J.W., Ruskin, J. Ventricular       pacing induced ventricular tachycardia in patients with implantable
cardioverter defibrillators J. Am. Coll. Of Cardiol February, 1994: Abstr #33A
Roelke, M., O'Nunain, S., Osswald, S., Garan, H., Harthorne, J.W., Ruskin, J.N. Subclavian crush syndrome complicating transvenous cardioverter defibrillator systems European Journal of Cardiac Pacing and Electrophysiology 1994: Vol 4, No. 2, Suppl. 2:140
Sweeney, M.O., Roelke, M., Jackson, G., Garan, H., Ruskin, J.N., Harthorne, J.W. Cephalic       vein approach for implantation of transvenous non-thoracotomy cardioverter-defibrillator       leads. J. Am. Coll. Of Cardiology 1996: 27(no 2):327A39.Heist, E,K., Harthorne, W., Singh, J. Pacing for AV Block NEJM 2005; 353;16: 1743
Narrative Report
The majority of my educational pursuits in earlier years involved cardiac catheterization techniques and the management of coronary artery disease syndromes including aortocoronary bypass grafting and endarterectomy for acute coronary syndromes and the surgical treatment of ischemic congestive heart failure. Since 1974, my interests have turned toward pacing and arrhythmia management.
The era when effective cardiac pacing devices were introduced for the management of cardiac arrhythmias coincided with the early stages of my career and has played a dominant role in my clinical as well as research interests. The early devices were cumbersome, and clunky in design with major deficiencies both in pacemaker lead design as well as pulse generator performance. The opportunity to participate as a consultant with two of the dominant manufacturers of pacing systems (Cordis Corporation in this country and Vitatron in Europe) offered the opportunity to blend the talents of the electronic design engineers with the clinical expertise in arrhythmia management of physician consultants. Collegial collaboration with cardiologists and surgeons involved in this technology has provided a mutual self education process to the betterment of patient care and improved device design. The resultant products include the original programmable dual chamber pacemaker produced by Cordis (Sequicor and Gemini models) and a variation of the adaptive rate pacemaker based on QT interval analysis produced by Vitatron (Quintech). This is reflected in a heavy lecture commitment in this country as well as overseas plus the annual commitment to work closely with a single cardiology trainee each year who gains expertise in over 300 device implant procedures. Such trainees (approximately 30 in number) now constitute recognized experts in pacing in this country as well as abroad. Prior work in the cardiac catheterization laboratory where an interest in hemodynamics prevailed led to collaborative studies as they relate to pacing and a number of publications that focused on contributions of atrial transport to ventricular function and patient well being confirmed by application of Doppler output methodology and quality of life protocols. In recent years, an interest in the interaction of environmental sources of electromagnetic interference with cardiac arrhythmia devices has lead to publications and oral presentations at national and international meetings on this topic as well as serving as an expert witness before government committees in this country and Europe.
The majority of my research interests in the past 25 years have involved clinical research that has been supported by income from private practice or donations from patients (MGH Fund 1200-64-028-784)
As a consultant to the American Medical Foundation (Philadelphia.Pa.) [Claude Welch was an original founding member], I perform in-depth analyses of hospital and physician performance of cardiac pacemaker procedures that have been found to be deficient during a Medicare or regional medical society review process culminating in their loss of accreditation. Such reviews involve 4-5 medical facilities annually with individual analyses of 75 – 100 patient records – each review culminating in a lengthy advisory document that offers a critique of the institution's weaknesses and recommended corrective procedures. I continue to work with MGH Cardiology trainees in teaching the techniques and technology of cardiac pacemakers and encouraging them to submit papers on these topics to various medical journals including PACE, the journal of pacing and electrophysiology of which I am an editorial board member.
In recent years, I have been called upon as a witness in the subject of electromagnetic interference and its impact upon patients with cardiac arrhythmia devices and have appeared before the Food and Drug Administration Safety Standards Committee in Bethesda, the FDA annual meeting in Boston, the New Hampshire State Legislative Technology Review Committee in Concord, N.H., and the German Government Technology Review Panel in Berlin to address various issues relative to electronic article surveillance systems (EAS) and other sources of EMI and cardiac device wearers.

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